GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1867631 | 1 | rs11208928 | chr1:67089562 | TCTEX1D1 | chr1:67218140-67244729:+ | 0.13 | 3.82 | 0.000139 | Menopause (age at onset) |
| BRCA | cis | rs7200543 | 1 | rs1121 | chr16:15131076 | C16orf63 | chr16:15959577-15982447:- | 0.13 | 3.56 | 0.00039 | Metabolic traits;Glycerophospholipid levels |
| BRCA | cis | rs4660306 | 1 | rs11211132 | chr1:45990516 | CCDC163P | chr1:45960581-45965646:- | -0.82 | -27.84 | 1.06E-128 | Homocysteine levels |
| BRCA | cis | rs4660306 | 1 | rs11211132 | chr1:45990516 | MMACHC | chr1:45965856-45976737:+ | -0.15 | -4.31 | 1.78E-5 | Homocysteine levels |
| BRCA | cis | rs2275426 | 1 | rs11211199 | chr1:46287869 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.78 | 3.2E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211199 | chr1:46287869 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.44 | 0.000595 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211199 | chr1:46287869 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5.05 | 5.23E-7 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211208 | chr1:46334256 | CCDC163P | chr1:45960581-45965646:- | -0.39 | -11.66 | 1.17E-29 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211208 | chr1:46334256 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.51 | 0.000471 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211208 | chr1:46334256 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5.19 | 2.49E-7 | Body mass index |
| BRCA | cis | rs1853207 | 1 | rs112112261 | chr10:96650048 | C10orf129 | chr10:96953957-96988685:+ | 0.34 | 5.47 | 5.73E-8 | Blood metabolite levels |
| BRCA | cis | rs2275426 | 1 | rs11211230 | chr1:46406767 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.8 | 2.8E-30 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211230 | chr1:46406767 | CCDC17 | chr1:46085717-46089729:- | 0.11 | 3.49 | 0.000496 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211230 | chr1:46406767 | MUTYH | chr1:45794915-45806142:- | 0.13 | 5.06 | 5.03E-7 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs11211234 | chr1:46438787 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.75 | 4.73E-30 | Body mass index |